Nucleotide sequencing of monoclonal rheumatoid factors from one of the patients' synovial tissue which contained germinal centres clearly supports the possibility that these rheumatoid factors have gone through a germinal centre reaction. There was a statistically significant association between follicles in the synovium and the presence of rheumatoid factor autoantibodies in the patients' serum indicating a link between local germinal centre formation and the presence of pathological rheumatoid factors. The synovial tissues of 14 patients contained follicles and four of these had germinal centres and a follicular dendritic cell network. Synovial tissue from 24 patients suffering from rheumatoid arthritis or the polyarticular form of juvenile rheumatoid arthritis were screened for the presence of lymphoid follicles. His vision and performance in The Good Ole Boys, certainly worth-while for fans, should round out his current body of work.We document here the identification of germinal centres with dark and light zones, a follicular dendritic cell network and clonal expansion in the synovium of rheumatoid arthritis patients. Currently TLJ enjoys worthy accolades for his roles in The Valley of Elah and No Country For Old Men, which should lead to inevitable Oscar nominations. What makes this most memorable are the aspects of very good story, memorable performances, and great visuals/sound score.
We witness familial love and hard decisions.
This story falls within the framework of time-honored classics where we get to see the impact of certain choices made and the ramifications as they unfold. The choices he acts upon effect all those around him, and then while his input and decision unfold, he then must decide if he will stick around in this New World to witness the results or return to the wide-open country. His leisurely life amongst cattle, horses and campfires is soon a distant memory. Soon our cowboy is thrust into the new world with new problems. After he sojourns back to the land of his roots, a beautiful and memorable story unfolds with the likes of Frances McDormand, Sissy Spacek, Sam Sheppard, Wilford Bremly and the (as far as I know) debut of Matt Damon waltz into the story to reveal hopes, dreams, missed opportunities and current dilemmas. The story shows us how a cowboy out on the vast range, isolated by big sweeping scenes, with only his horse to keep him company, enters into the new century.
He eventually heads home and then we are drawn into a turn of the century frontier settlement juxtapositioned with the old west sweeping sky lines and open ranges slowly encroached by the advent of Westward Expansion and technology. In the opening scenes, we watch a cowboy as he and his horse graze the high country a scene that could occur at any time within our frontier history. It is a classic Western that is as priceless as anything given to us from both Johns Wayne and Ford. The product is a Western equally worthy of mentioning in the same short list as Unforgiven, Silverado, 3:10 to Yuma and recent others. What ensued was The Good Ole Boys as we know it.
He wanted more than Turner and his execs were offering as the lead actor, but agreed to sign on to the project for less if he could be given free reign to direct, which was a bargain for the price. As I recall from trade mags, back when this flick first came out, TNT approached TLJ to be the lead, but at the time, he was pondering his future in the film industry and was considering directing.